Naloxone HCl
357-08-4
General information
Naloxone is an opioid antagonist: a medication used to reverse or reduce the effects of opioids. For example, it is used to restore breathing after an opioid overdose. Effects begin within two minutes when given intravenously, five minutes when injected into a muscle, and ten minutes as a nasal spray. Naloxone blocks the effects of opioids for 30 to 90 minutes. Naloxone is poorly absorbed when taken by mouth, so it is combined with a number of oral opioid preparations, including buprenorphine, oxycodone, and tilidine, so that when taken by mouth, only the opioid has an effect.
Trade names
Narcan, Nyxoid
About the API
Therapeutic areas
Opioid antagonist
Available grades
Various milled & micronized
Monographs
USP, Ph. Eur.
Regulatory documentation
CEP / USDMF
Production location
Minden
Standard pack size
1kg, 5kg, 25kg
Physical properties
White or almost white hygroscopic powder
Typical formulation types
Nasal, injectable