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Naloxone HCl


General information

Naloxone is an opioid antagonist: a medication used to reverse or reduce the effects of opioids. For example, it is used to restore breathing after an opioid overdose. Effects begin within two minutes when given intravenously, five minutes when injected into a muscle, and ten minutes as a nasal spray. Naloxone blocks the effects of opioids for 30 to 90 minutes. Naloxone is poorly absorbed when taken by mouth, so it is combined with a number of oral opioid preparations, including buprenorphine, oxycodone, and tilidine, so that when taken by mouth, only the opioid has an effect.

Trade names

Narcan, Nyxoid

About the API

Therapeutic areas

Opioid antagonist

Available grades

Various milled & micronized


USP, Ph. Eur.

Regulatory documentation


Production location


Standard pack size

1kg, 5kg, 25kg

Physical properties

White or almost white hygroscopic powder

Typical formulation types

Nasal, injectable

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