Pilot Manufacturing and Scale up

Siegfried can help you save time & accelerate your drug development via our versatile cGMP pilot manufacturing & scale-up capabilities. Our core strength is taking a chemical process from development and scaling it up into a cost-effective & robust manufacturing process.

For drug substance pilot manufacturing Siegfried offers four production sites:  Zofingen (Switzerland), Evionnaz (Switzerland), Nantong (China), and Pennsville (USA).

With Siegfried you are able to profit from a vast knowledge acquired from over 1,600 chemical development projects. Over the last ten years alone, Siegfried’s chemists have commercialized over 50 New Chemical Entities (NCEs) and applied a range of chemistries.

Whether it is a new or modified process generated from our chemical development or an existing process received directly from our customers, we are able to quickly and efficiently take the process to the next manufacturing stage required. We are able to support your various material needs from early clinical trials through to commercial launch and routine manufacturing.

Pilot Plant (Zofingen, Switzerland)

  • steel, glass-lined and hastelloy C22 reactors (63-630 liters)
  • 63, 259 liters hastelloy and 630 liters glass-lined reactors for pressure reactions (15 bar) 
  • temperature range -60°C to 220°C
  • short path distillation line
  • centrifuges, nutsche filter
  • paddle, spherical, filter and tray dryers (up to 400 liters)
  • Fitzpatrick and Frewitt mills
  • Jet mill micronizer

Kilo Lab & Pilot Plant (Evionnaz, Switzerland)

  • stainless steel, glass-lined and hastelloy C22 reactors (10-1000 liters)
  • 800 liters hastelloy C22 reactor for cryogenic reactions (-100°C) 
  • 250 liters glass-lined reactor for pressure reactions (11 bar) 
  • 1 segregated chamber for hazardous reactions
  • stand-alone unit concept : reactor, condenser & receiver, units interconnected & connected to filters, centrifuges or other devices with flexible hoses.
  • temperature range -100°C to 250°C
  • 15 theoretical plates distillation line
  • centrifuges, nutsche filter
  • tumble, filter and tray dryers

Pilot Plant (Pennsville, USA)

  • stainless steel and glass-lined reactors (40-2000 liters)
  • 100-700 liter steel reactor for pressure reactions (6.5 bar) 
  • temperature range -10°C to 170°C
  • 14” Ø centrifuge, nutsche filter
  • rotary dryer (140 liter) and tray dryers
  • spray dryer 
  • jet mill micronizer
  • Hosokawa, cone and Fitzpatrick mills

Pilot Plant (Nantong, China)

  • steel and glass-lined reactors (100-2000 liters)
  • temperature range -19°C to 180°C
  • 200 liters steel reactor for pressure reactions (60 bar)
  • 200 liters glass-lined reactors for pressure reactions (10 bar)
  • 200 liters high/low temperature reactor, temperature range -100°C to 250°C
  • stainless steel mobile bag filters and Halar coated mobile tanks
  • centrifuge, nutsche filters
  • Halar coated tray dryers

Expect more with Siegfried as your preferred Service Partner

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Siegfried AG
Untere Bruehlstrasse 4
CH-4800 Zofingen

Phone: +41 62 746 1111
Fax: +41 62 746 1202
info@siegfried.ch