Manufacturing

Siegfried, as a flexible partner, provides reliable and consistent commercial supply combined with good quality product and performance. We do this by providing our customer’s versatile cGMP manufacturing capability and robust manufacturing processes suitable for specific market needs.

For drug substance manufacturing, Siegfried offers six production sites: Zofingen (Switzerland), Pennsville (USA), Nantong (China), Minden (Germany), Evionnaz (Switzerland), and St. Vulbas (France). All sites are fully cGMP compliant with an outstanding inspection history

Siegfried offers extensive experience & expertise in manufacturing Active Pharmaceutical Ingredients (APIs) and key intermediates for exclusive customers, and an independent know-how through a portfolio of non-exclusive products.  Also, we offer an extensive range of chemistries & process capabilities at production scale to efficiently manufacture demanding drug substances, intermediates and complex synthetic processes. Among the range of materials produced are controlled substances and high potency materials.

In addition to the synthetic chemistry, Siegfried ensures that the final isolation & finishing processes (crystallization, drying, milling, blending and packaging) are performed in separately controlled areas.  Siegfried has applied drying units which utilize the latest double air-lock systems available.  When possible, solvents are recycled using our extensive rectification capacity. 

Whatever your production requirements may be, please contact Siegfried, as we would be delighted to service your needs.

Zofingen (Switzerland) Facilities

Annual outputApprox. 1,500 metric tons final APIs
Output range per product  0.5 - 900 metric tons
Total multi-purpose reactor volume 350 m3
Range of reactor volumes 800 - 5,000 liters (stainless steel, glass-lined, Hastelloy C22) 
Number of reactors120
Temperature range -90 to 250°C
Pressure range 1 mbar to 40 bar
Product isolation Centrifuges, nutsch filters, filter press, Titus-type centrifuge dryer
Drying capacity 25 m3 (10 dryers 200 - 2,500 liters)
Services Custom manufacturing, full-scale validation, DMF, COS
Special equipment Mills and sieves, KD 10 short path distillation, efficient Biazzi high pressure hydrogenation reactor, special bromination, chlorination unit

Pennsville (USA) Facilities

Annual output 300 metric tons final APIs
Output range 5 kg - 150 metric tons
Total multi-purpose reactor volume 233 m3
Range of reactor volumes 100 – 7,600 liters (stainless steel, glass lined, Hastelloy C22)
Number of reactors52
Temperature range -15 to 180°C
(special equipment up to 350°C) 
Pressure range 1 mbar to 8 bar 
Product isolation Centrifuges, filter presses, Heinkel inverting basket centrifuge
Drying capacity 23 m3 (13 dryers 100l – 4.5m3) including a pilot and a commercial spray dryer
Special equipment Sieves, mills and micronizer in IH class 1µg/ m3

Nantong (China) Facilities

Annual output2,500 metric tons final APIs and intermediates
Output range per product 0.1 - 500 metric tons
Total multi-purpose reactor175 m3 for API and 175 m3 for intermediates
Range of reactor volumes 1,600 - 10,000 lieters (stainless steel, glass-lined, Hastelloy C22)
Number of reactors58
Temperature range-100 to 250°C
Pressure range 1 mbar to 65 bar
Product isolation Centrifuges, nutsch filters
Drying capacits
Services
36 m3 (9 dryers 2,000 - 6,000 liters)
Custom manufacturing, full-scale validation
Special equipment Mills and sieves, short path distillation, high pressure hydrogenation reactor, special bromination, chlorination unit, high and low temperature

Minden (Germany) Facilities

Annual output Approx. 4,000 metric tons final APIs
Output range per product2,500 metric tons
Total multi-purpose reactor volume185 m3
Range of reactor volumes 800 - 10,000 liters (stainless steel, glass-lined) 
Number of reactors64
Temperature range -15 to 260°C
Pressure range 1 mbar to 10 bar
Product isolation Distillation columns with approx. 40 and 94 theoretical plates, Centrifuges (horizontal, vertical, inverting) nutsch filters, filter dryer, paddle dryers
Drying capacity 8.6 m3 (5 dryers 800 – 2,400 liters) 
Services Exclusive and portfolio APIs and Intermediates
Special equipment Cyanization equipment
Fermentation reactors
Photochemistry reactors
Ion exchange unit
Hydrogenation units with catalyst-reactivation equipment
Mechanical & jet mills, sieves

Evionnaz (Switzerland) Facilities

Total multi-purpose reactor volume 315 m3
Facility lay out concept Flexible set up tailored to meet any process
Stand-alone units are connected at will with flexible hoses to build production trains
Range of reactor volumes 2,000 - 8,000 liters (stainless steel, glass-lined, Hastelloy C22) 
Number of reactors75
Temperature range -20 to 150°C (200°C on specific reactors)
Pressure range 1 mbar to 6 bar (12 bar on specific reactors)
Product isolation 32 theoretical plate distillation columns, thin layer evaporators (stainless steel and glass-lined)
Centrifuges, nutsch filters, filter dryer, tumble dryer
Drying capacity 36 m3 (14 dryers 1,000 – 4,000 liters) 
Services Exclusive and portfolio APIs and Intermediates
Special equipment 4 segregated chambers for hazardous reactions
cGMP Phosgen generator (200 kg/Hr)
secured bunker for Azide chemistry
special bromination and hydrogenation units
Mills and sieves

St. Vulbas (France) Facilities

Total multi-purpose reactor volume141 m3
Facility lay out concept Flexible set up tailored to meet any process
Stand-alone units are connected at will with flexible hoses to build production trains
Range of reactor volumes 2,500 - 8,000 liters (stainless steel, glass-lined, Hastelloy C22) 
Number of reactors28
Temperature range -100 to 140°C (200°C on specific reactors)
Pressure range 1 mbar to 6 bar
Product isolation 16 theoretical plate distillation column
Centrifuges, nutsch filters, filter press, filter dryer
Drying capacity 31 m3 (8 dryers 3,500 – 4,000 liters) 
Services Exclusive and portfolio APIs and Intermediates
Special equipment 3 segregated chambers for hazardous reactions
cryogenic reactors (4,000 and 6,000 liters)
cGMP Phosgen generator (160kg/Hr – up to 300kg/Hr)
special bromination and hydrogenation units

Expect more with Siegfried as your preferred Service Partner

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Siegfried AG
Untere Bruehlstrasse 4
CH-4800 Zofingen

Phone: +41 62 746 1111
Fax: +41 62 746 1202
info@siegfried.ch