Pilot Manufacturing & Scale-up
Siegfried can help you save time and speed up your drug substance development with our versatile cGMP pilot manufacturing and scale-up capabilities. One of our core strengths lies in taking a chemical process in development and scaling it up into a cost-effective and robust manufacturing process suitable for your specific market needs.
When you partner with Siegfried, you benefit from the vast knowledge acquired from over 1,600 chemical development projects. Siegfried’s process chemists are world-class leaders in developing commercially viable, robust and scalable processes. They can apply a range of chemistries available at production. Our chemists have made over 50 full-scale plant introductions of small-molecule New Chemical Entities (NCEs) within the last ten years alone.
For drug substance pilot manufacturing Siegfried offers two production sites for drug substance pilot manufacturing: Zofingen, Switzerland, and Pennsville, New Jersey, USA.
Whether it is a new or a modified process generated from our chemical development, or an existing process received directly from our customers, we have the expertise to take the process to the next manufacturing stage, quickly and efficiently. We are able to support your various material needs from early clinical trials right through to commercial launch and routine manufacturing.
Pilot plant (Zofingen, Switzerland)
- steel and glass-lined reactors (250-500 liters)
- 350 liters steel reactor for pressure reactions (15 bar)
- temperature range -40°C to 220°C
- short path distillation line
- centrifuge, nutsche filter
- paddle dryer (400 liters)
- Alpine and Fitzpatrick mills
Pilot plant (Pennsville, New Jersey, USA)
- steel and glass-lined reactors (40-2000 liters)
- 100-700 liter steel reactor for pressure reactions (6.5 bar)
- temperature range -10°C to 170°C
- 14” Ø centrifuge, nutsche filter
- rotary dryer (140 liter) and tray dryers
- spray dryer
- jet mill micronizer
- Hosokawa, cone and Fitzpatrick mills