Manufacturing
With Siegfried as your flexible partner, you can expect a reliable and consistent commercial supply along with good quality product and performance. We have a proven track record of providing versatile cGMP manufacturing capability and robust manufacturing processes that suit our customers’ market needs.
Siegfried offers two production sites for drug substance manufacturing: Zofingen, Switzerland, and Pennsville, New Jersey, USA. Both sites are fully cGMP compliant with an outstanding inspection history.
Siegfried offers extensive experience and expertise in manufacturing Active Pharmaceutical Ingredients (APIs) and key intermediates for exclusive customers, as well as the independent know-how from our own portfolio of non-exclusive products. We also offer an extensive range of chemistries and process capabilities at production scale to efficiently manufacture demanding drug substances, intermediates and complex synthetic processes. Among the range of materials produced are controlled substances and high potency materials.
In addition to synthetic chemistry, Siegfried ensures the final isolation & finishing processes (crystallization, drying, milling, blending and packaging) are performed in separate controlled areas. Siegfried applies drying units that utilize the latest technology in double air-lock systems. Whenever possible, solvents are recycled using our extensive rectification capacity.
Whatever your production requirements may be, expect more when you partner with Siegfried.
Zofingen, Switzerland facilities | |
Annual output | 1,500 metric tons final API‘s |
Output range per product | 0.5 - 900 metric tons |
Total multi-purpose reactor volume | 350 m³ |
Range of reactor volumes | 800 - 5,000 liters (stainless steel, |
Number of reactors | 120 |
Temperature range | -90 to 250°C |
Pressure range | 1 mbar to 40 bar |
Product isolation | Centrifuges, nutsch filters, filter press, Titus-type centrifuge dryer |
Drying capacity | 25 m³ (11 dryers 200 - 2,500 liters) |
Services | Custom manufacturing, full-scale validation, DMF, COS |
Special equipment | Mills and sieves, KD 10 short path distillation, efficient Biazzi high pressure hydrogenation reactor, special bromination, chlorination unit |
Pennsville, NJ (U.S.A. ) facilities | |
Annual output | 300 metric tons final APIs |
Output range per product | 5 kg - 150 metric tons |
Total multi-purpose reactor volume | 200 m³ |
Range of reactor volumes | 100 – 7,600 liters (stainless steel, glass lined, Hastelloy C22) |
Number of reactors | 52 |
Temperature range | -15 to 180°C |
Pressure range | 1 mbar to 8 bar |
Product isolation | Centrifuges, filter presses, Heinkel inverting basket centrifuge |
Drying capacity | 23 m³ (13 dryers 100l – 4.5 m³) including a pilot and a commercial spray dryer |
Special equipment | Sieves, mills and micronizer in IH class 1µg/m³ |