Pilot Manufacturing and Scale-up

Siegfried can you help save time and speed up your drug product development with our versatile cGMP pilot manufacturing & scale-up capabilities. Whether you need a formulation in development scaled up into a cost-effective and robust manufacturing process or if you need support with your clinical trial material needs, you can expect more from Siegfried’s pilot manufacturing and scale-up expertise.

We take your process to the next manufacturing stage quickly and smoothly regardless of your starting point, whether it’s is a new, modified or existing formulation generated by our Pharmaceutical development team. Siegfried is able to support all your material needs, from the early clinical phase through to commercial launch and routine manufacturing.


In addition, Siegfried offers drug product pilot scale-up manufacturing under cGMP conditions at our Zofingen site in Switzerland, certified by SwissMedic. A Qualified Person releases all manufacturing and analysis for subsequent application and processing.

Because of our versatile breadth of equipment types and size we’re able to manufacture clinical trial material at scales ranging from very small quantities to pilot batches, depending on your specific needs, including:

• Intensive mixing and wet granulation
• Fluid bed granulation/drying
• Roller compaction
• Single pot granulation (also suitable for organic solvents and hot-melt granulates)
• Tabletting via instrumented rotary presses (incl. minitablets)
• Pellet extrusion and spheronization
• Film coating of granulates, pellets or tablets
• Filling of hard gelatin capsules with powder mixtures, pellets, minitablets, fluids

Siegfried also has a separate area for handling high potency substances to manufacture clinical samples and stability batches for APIs with occupational exposure limits of 1-10 µg/m³ under cGMP conditions.