Manufacturing

As your flexible partner, Siegfried provides reliable and consistent commercial supply combined with high quality product and performance. We provide versatile cGMP manufacturing capability and robust manufacturing processes that meet your unique market needs.

Siegfried maintains GMP-certified and FDA-audited manufacturing plants for custom development and commercial manufacture of solid, oral pharmaceutical dosage forms, such as granulates, tablets, film tablets and hard capsules filled with powder or pellets.

Clinical trial drugs and smaller manufacturing batches are produced in our pilot plant in Zofingen, Switzerland, while commercial manufacture takes place at our full-scale production facility in Malta.

Both locations have a multitude of technologies that are equipped to manufacture various solid oral dosage forms, including:

• High shear mixer
• Fluid bed systems with top and bottom spray (Wurster)
• Perforated drum coater
• Tablet presses
• Capsule machines
• Blister lines for thermoform and cold form blister packaging

We can handle a broad range of batch sizes (0.5kg - 350kg) because of Siegfried’s numerous container sizes, ranging from free-fall mixing to film coating. Our equipment types are selected to match and harmonize with one another, ensuring simple scale-up.

In addition to the processing of standard active substances (occupational exposure limit -OEL >10 µg/m³), both manufacturing plants have an additional, segregated area to process highly-active and low-dose substances (OEL 1-10 µg/m³) to pharmaceutical dosage forms. The separate contained operating areas have various engineering measures (e.g., machine containment) in place, to guarantee the product’s protection and the safety of employees and environment. 

For more information about our manufacturing facilities and their corresponding equipment, please contact Business Development. Whatever your production requirements may be, you can expect more from Siegfried.