Formulation Capabilities

To help you succeed with your product’s development & manufacturing goals Siegfried offers a broad spectrum of technologies for the development and manufacture of solid dosage forms, ranging from rapid-release tablets to controlled-release formulations. Based on more than 30 years of experience & application with an extensive range & type of products, our customers gain more knowledge, innovation & technological expertise in the following areas:

• Wet- and melt granulation in high shear mixer
• Fluid bed granulation / drying
• Roller compacting
• One pot granulation
• Tabletting (incl. minitablets)
• Pellet extrusion and spheronization
• Film coating (granulates, pellets, tablets)
• Hard gelatin capsules (with granulates, powders, pellets, tablets, fluids)
• Blister packaging (thermo- and cold-form blister packaging)
• Bottle filling systems

• Mixing of powders
• Wet- and melt granulation in one pot granulator
• Tabletting
• Film coating (tablets)
• Hard gelatin capsules (with granulates, powders, pellets)
• Blister packaging (thermo– and cold-form blister packaging)
• Bottles / Filling systems

Additionally, Siegfried is planning to expand its services through hot-melt extrusion, gastro-retentive formulations, and others.

• Analytical method development and validation (e.g. dicrimantory dissolution method, content uniformity, enantiomeric purity etc.)
• Development and validation of cleaning validation methods
• Forced degradation and stability investigations of prototypes for optimization of the final formulation and packaging
• Photostability investigations in accordance with ICH Guidelines