Chemistry Capabilities
Siegfried has vast experience with reactions from the following classes
C-C Bonds
- Aldol reactions (Knoevenagel condensation, Dieckmann, etc.)
- Baylis-Hillman reaction
- Blanc chloromethylation
- Diels-Alder reaction
- Fries rearrangement
- Favorskii reaction
- (Mizoroki-)Heck reaction
- Grignard reaction
- Mannich reaction
- Michael reaction
- Suzuki reaction
- Wittig reaction
C-Heteroatom Bond Forming Reactions
- Alkylations
- Buchwald-Hartwig amination
- Mannich reaction
- Leuckart reaction
- Reductive amination
- Ritter reaction
Chiral Resolutions
- Enzyme-catalyzed kinetic resolutions of racemic esters
- Chiral (racemic) resolutions using diastereomeric salts
Chiral Catalysis
- Enzymatic saponification
- Chiral reduction
- Sharpless dihydroxylation (Bishydroxylation)
Metal-organic Reactions
- Boronic acids
- Grignard reaction
- Lithium-Halogen exchange
- Ortho-Lithiation
- Reformatsky reaction
- Organozinc reaction
Homogenous Catalysis by Noble Metals
- Asymmetric hydrogenation
- Buchwald-Hartwig amination
- Carbonylation of haloaromatics (CO insertion)
- Heck reaction
- Sharpless dihydroxylation (bishydroxylation)
- Suzuki reaction
Aromatic Ring Substitutions
- Bromination
- Chlorination
- Chlorosulfonation
- Diazo alkylation
- Friedel-Crafts acylations
- Friedel-Crafts alkylations
- Gattermann aldehyde synthesis
- Nitration
- Vilsmeier-Haack reaction
Functional Group Transformation
- Alcoholysis
- Aminolysis
- Amidation
- Finkelstein reaction
- Hofmann rearrangement
- N-Demethylations (from Braun reaction, etc.)
- O-Demethylations
- Ritter reaction
- Sandmeyer reaction
- Esterification
Reductions and Oxidations
- Alkene reductions
- Chiral reductions
- Heterogenous catalysis
- Homogenous catalysis
- Meerwein-Ponndorf-Verley (MPV) reduction
- Oxidation of non-substituted C-structures
- Reductive amination
- Reduction of nitrogen bonds
- Swern oxidation
- Wolff-Kishner reduction
Cyclizations
- Heteroatom cyclizations
- Diels-Alder reaction
- Fischer indole synthesis
- Hantzsch pyrrole synthesis
- Hantzsch pyridine synthesis
- Knorr pyrrole synthesis
Protecting Group Chemistry
- Acetal
- Benzyl
- BOC
- CBZ
- Silyl ethers (TMS, TBDMS, ..)
Reactions with Special Chemicals
- Borane
- Cyanogen bromide
- Dimethyl sulfate
- Epichlorohydrin
- Halogens (chlorine, bromine, iodine)
- Phosgene, triphosgene
- Etc.
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